期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 119, 期 9, 页码 2475-2487出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI38605
关键词
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资金
- United Kingdom National Institute of Health Research, through Nottingham Digestive Diseases Centre Biomedical Research Unit in Gastrointestinal and Liver Disease
- Medical Research Council United Kingdom
- Cancer Research UK
- CORE (the United Kingdom digestive diseases charity)
- NIH [RO1 GM63270]
- MRC [G0601170] Funding Source: UKRI
- Medical Research Council [G0601170] Funding Source: researchfish
Humans have been colonized by Helicobacterpylori for at least 50,000 years and probably throughout their evolution. H. pylori has adapted to humans, colonizing children and persisting throughout life. Most strains possess factors that subtly modulate the host environment, increasing the risk of peptic ulceration, gastric adenocarcinoma, and possibly other diseases. H. pylori genes encoding these and other factors rapidly evolve through mutation and recombination, changing the bacteria-host interaction. Although immune and physiologic responses to H. pylori also contribute to pathogenesis, humans have evolved in concert with the bacterium, and its recent absence throughout the life of many individuals has led to new human physiological changes. These may have contributed to recent increases in esophageal adenocarcinoma and, more speculatively, other modern diseases.
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