相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Recent progress in the identification and clinical evaluation of inhibitors of the mitotic kinesin KSP
Steven D. Knight et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2008)
Misinterpreting the therapeutic effects of siRNA caused by immune stimulation
Marjorie Robbins et al.
HUMAN GENE THERAPY (2008)
Overcoming the innate immune response to small interfering RNA
Adam Judge et al.
HUMAN GENE THERAPY (2008)
An efficient and low immunostimulatory nanoparticle formulation for systemic siRNA delivery to the tumor
Sumio Chono et al.
JOURNAL OF CONTROLLED RELEASE (2008)
Sequence- and target-independent angiogenesis suppression by siRNA via TLR3
Mark E. Kleinman et al.
NATURE (2008)
Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target
Dan Peer et al.
SCIENCE (2008)
Pharmacological and functional comparison of the polo-like kinase family: Insight into inhibitor and substrate specificity
Eric F. Johnson et al.
BIOCHEMISTRY (2007)
Rational combinations of siRNAs targeting Plk1 with breast cancer drugs
B. Spaenkuch et al.
ONCOGENE (2007)
Interfering with disease: a progress report on siRNA-based therapeutics
Antonin de Fougerolles et al.
NATURE REVIEWS DRUG DISCOVERY (2007)
Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA
Jeremy D. Heidel et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1
Peter Lenart et al.
CURRENT BIOLOGY (2007)
BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo
Martin Steegmaier et al.
CURRENT BIOLOGY (2007)
Cell cycle kinases in cancer
Marcos Malumbres et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2007)
Nucleic acid agonists for toll-like receptor 7 are defined by the presence of uridine ribonucleotides
Sandra S. Diebold et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2006)
5′-triphosphate RNA is the ligand for RIG-I
Veit Hornung et al.
SCIENCE (2006)
Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance
Campbell McInnes et al.
NATURE CHEMICAL BIOLOGY (2006)
RNA interference in the mouse vascular endothelium by systemic administration of siRNA-lipoplexes for cancer therapy
A. Santel et al.
GENE THERAPY (2006)
A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium
A. Santel et al.
GENE THERAPY (2006)
Synthesis and characterization of novel poly(ethylene glycol)-lipid conjugates suitable for use in drug delivery
James Heyes et al.
JOURNAL OF CONTROLLED RELEASE (2006)
RNAi-mediated gene silencing in non-human primates
TS Zimmermann et al.
NATURE (2006)
A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells
JT Marques et al.
NATURE BIOTECHNOLOGY (2006)
Opinion - Targeting polo-like kinase 1 for cancer therapy
K Strebhardt et al.
NATURE REVIEWS CANCER (2006)
Progress towards in vivo use of siRNAs
MA Behlke
MOLECULAR THERAPY (2006)
Thymidine-phosphorothioate oligonucleotides induce activation and apoptosis of CLL cells independently of CpG motifs or BCL-2 gene interference
JE Castro et al.
LEUKEMIA (2006)
Cleavage of the siRNA passenger strand during RISC assembly in human cells
PJF Leuschner et al.
EMBO REPORTS (2006)
Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo
AD Judge et al.
MOLECULAR THERAPY (2006)
Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging
DW Bartlett et al.
NUCLEIC ACIDS RESEARCH (2006)
Synergistic activation of macrophages via CD40 and TLR9 results in T cell independent antitumor effects
IN Buhtoiarov et al.
JOURNAL OF IMMUNOLOGY (2006)
Therapeutic potential of Toll-like receptor 9 activation
Arthur M. Krieg
NATURE REVIEWS DRUG DISCOVERY (2006)
Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes
C Matranga et al.
CELL (2005)
Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs
DV Morrissey et al.
NATURE BIOTECHNOLOGY (2005)
Induction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage
WK Tao et al.
CANCER CELL (2005)
Positional effect of chemical modifications on short interference RNA activity in mammalian cells
TP Prakash et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Stabilized plasmid-lipid particles containing PEG-diacylglycerols exhibit extended circulation lifetimes and tumor selective gene expression
E Ambegia et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2005)
Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
AD Judge et al.
NATURE BIOTECHNOLOGY (2005)
RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo
B Urban-Klein et al.
GENE THERAPY (2005)
Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7
V Hornung et al.
NATURE MEDICINE (2005)
RNA interference and chemically modified small interfering RNAs
M Manoharan
CURRENT OPINION IN CHEMICAL BIOLOGY (2004)
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
J Soutschek et al.
NATURE (2004)
Polo-like kinases and the orchestration of cell division
FA Barr et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2004)
Asymmetry in the assembly of the RNAi enzyme complex
DS Schwarz et al.
CELL (2003)
siRNA function in RNAi: A chemical modification analysis
YL Chiu et al.
RNA (2003)
Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells
F Czauderna et al.
NUCLEIC ACIDS RESEARCH (2003)
Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells
XQ Liu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Double-stranded RNA signaling by toll-like receptor 3 requires specific tyrosine residues in its cytoplasmic domain
SN Sarkar et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Effect of RNA silencing of polo-like kinase-1 (PLK1) on apoptosis and spindle formation in human cancer cells
B Spänkuch-Schmitt et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2002)
A comprehensive view of regulation of gene expression by double-stranded RNA-mediated cell signaling
G Geiss et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
SM Elbashir et al.
NATURE (2001)
RNA interference is mediated by 21-and 22-nucleotide RNAs
SM Elbashir et al.
GENES & DEVELOPMENT (2001)