4.8 Article

Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Pharmacology & Pharmacy

Development and application of Hsp90 inhibitors

David B. Solit et al.

DRUG DISCOVERY TODAY (2008)

Review Pharmacology & Pharmacy

Mitochondrial medicine: Pharmacological targeting of mitochondria in disease

J. S. Armstrong

BRITISH JOURNAL OF PHARMACOLOGY (2007)

Article Multidisciplinary Sciences

The genomic landscapes of human breast and colorectal cancers

Laura D. Wood et al.

SCIENCE (2007)

Article Biochemistry & Molecular Biology

Diverse cellular functions of the Hsp90 molecular chaperone uncovered using systems approaches

Amie J. McClellan et al.

Article Biochemistry & Molecular Biology

Heat shock protein 75 (TRAP1) antagonizes reactive oxygen species generation and protects cells from granzyme M-mediated apoptosis

Guoqiang Hua et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

A Bax/Bak-independent mechanism of cytochrome c release

Takeshi Mizuta et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Cell Biology

Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death

Christopher P. Baines et al.

NATURE CELL BIOLOGY (2007)

Article Multidisciplinary Sciences

The consensus coding sequences of human breast and colorectal cancers

Tobias Sjoeblom et al.

SCIENCE (2006)

Article Multidisciplinary Sciences

Hsp90 inhibition transiently activates Src kinase and promotes Src-dependent Akt and Erk activation

Fumitaka Koga et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Biochemistry & Molecular Biology

Chaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperones

SJH Arlander et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Review Biochemistry & Molecular Biology

A control theoretic paradigm for cell signaling networks: a simple complexity for a sensitive robustness

RP Araujo et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2006)

Article Biotechnology & Applied Microbiology

Innovation -: Rescuing drug discovery:: in vivo systems pathology and systems pharmacology

J van der Greef et al.

NATURE REVIEWS DRUG DISCOVERY (2005)

Review Oncology

Promoting apoptosis as a strategy for cancer drug discovery

SW Fesik

NATURE REVIEWS CANCER (2005)

Review Medicine, Research & Experimental

Mitochondria: pharmacological manipulation of cell death

L Bouchier-Hayes et al.

JOURNAL OF CLINICAL INVESTIGATION (2005)

Review Medicine, Research & Experimental

Reawakening the cellular death program in neoplasia through the therapeutic blockade of IAP function

CW Wright et al.

JOURNAL OF CLINICAL INVESTIGATION (2005)

Article Multidisciplinary Sciences

Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia

AC Schinzel et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Review Biochemistry & Molecular Biology

Systems modeling: a pathway to drug discovery

P Rajasethupathy et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Compartmentalized signalling of Ras

MR Philips

BIOCHEMICAL SOCIETY TRANSACTIONS (2005)

Article Biotechnology & Applied Microbiology

Can cell systems biology rescue drug discovery?

EC Butcher

NATURE REVIEWS DRUG DISCOVERY (2005)

Article Oncology

Rational design of shepherdin, a novel anticancer agent

J Plescia et al.

CANCER CELL (2005)

Article Chemistry, Multidisciplinary

Highly efficient, nonpeptidic oligoguanidinium vectors that selectively internalize into mitochondria

J Fernandex-Carneado et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)

Review Biochemistry & Molecular Biology

Cancer genes and the pathways they control

B Vogelstein et al.

NATURE MEDICINE (2004)

Review Multidisciplinary Sciences

The pathophysiology of mitochondrial cell death

DR Green et al.

SCIENCE (2004)

Article Multidisciplinary Sciences

Targeted cancer therapy

C Sawyers

NATURE (2004)

Review Multidisciplinary Sciences

Oncogenomics and the development of new cancer therapies

RL Strausberg et al.

NATURE (2004)

Article Oncology

Clinical Development of 17-Allylamino, 17-Demethoxygeldanamycin

Edward A. Sausville et al.

CURRENT CANCER DRUG TARGETS (2003)

Article Multidisciplinary Sciences

Disassembly of transcriptional regulatory complexes by molecular chaperones

BC Freeman et al.

SCIENCE (2002)

Review Cell Biology

Hsp90: a specialized but essential protein-folding tool

JC Young et al.

JOURNAL OF CELL BIOLOGY (2001)

Article Biochemistry & Molecular Biology

The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties

SJ Felts et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

Article Oncology

Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins

MG Marcu et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2000)

Review Biochemistry & Molecular Biology

Structure and in vivo function of Hsp90

LH Pearl et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2000)