期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 118, 期 4, 页码 1266-1276出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI33996
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资金
- NIAID NIH HHS [R01 AI058973-02, R01 AI058973] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI058973] Funding Source: NIH RePORTER
There are still approximately 500 million cases of malaria and 1 million deaths from malaria each year. Yet recently, malaria incidence has been dramatically reduced in some parts of Africa by increasing deployment of anti-mosquito measures and new artemisinin-containing treatments, prompting renewed calls for global eradication. However, treatment and mosquito control currently depend on too few compounds and thus are vulnerable to the emergence of compound-resistant parasites and mosquitoes. As discussed in this Review, new drugs, vaccines, and insecticides, as well as improved surveillance methods, are research priorities. Insights into parasite biology, human immunity, and vector behavior will guide efforts to translate parasite and mosquito genome sequences into novel interventions.
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