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Shao H. Yang et al.
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A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation
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A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria
LG Fong et al.
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LG Fong et al.
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SG Young et al.
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Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition
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MP Mallampalli et al.
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Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome
BC Capell et al.
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Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes
JI Toth et al.
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Tools to analyze protein farnesylation in cells
JM Troutman et al.
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Expression of an LMNA-N195K variant of A-type lamins results in cardiac conduction defects and death in mice
LC Mounkes et al.
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Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation
SH Yang et al.
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Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome
P Scaffidi et al.
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J Kirschner et al.
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Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome
RD Goldman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
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M Eriksson et al.
NATURE (2003)
Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)