期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 118, 期 7, 页码 2372-2379出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI33452
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资金
- NHLBI NIH HHS [R01 HL087118] Funding Source: Medline
Recent investigations have suggested that it might be possible to reverse the pathology of pulmonary arterial hypertension (PAH), a disorder that can be rapidly progressive and fatal despite current treatments including i.v. prostacyclin. This review will address the cellular and molecular processes implicated in clinical, genetic, and experimental studies as underlying the pulmo nary vascular abnormalities associated with PAH. Emerging treatments are aimed at inducing apoptosis of abnormal vascular cells that obstruct blood flow and at promoting regeneration of lost distal vasculature.
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