期刊
JOURNAL OF CLINICAL GASTROENTEROLOGY
卷 45, 期 2, 页码 149-152出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MCG.0b013e3181e12c24
关键词
antibodies to endotoxin; EndoCab; nonalcoholic fatty liver disease; leaky gut
资金
- Senter Novem Innovation Oriented Research Program on Genomics [IGE05012]
- Transnational University Limburg (TUL)
Background: Endotoxin is hypothesized to play an important role in the activation of inflammatory pathways associated with nonalcoholic steatohepatitis (NASH). However, demonstration of hepatic endotoxin exposure is challenging due to the inaccessibility of the portal circulation. Furthermore, reliable measurement of the relatively low endotoxin levels in plasma of patients with liver disease and subsequent interpretation remain difficult. Goals: In this study, we used the EndoCab assay that measures endogenous antibodies to the core region of endotoxin to estimate hepatic endotoxin exposure over time. Study: IgG levels against endotoxin were measured in peripheral plasma obtained from 21 severely obese patients with NASH and 9 severely obese patients with healthy livers. Results: Plasma IgG levels against endotoxin were significantly elevated in patients with NASH compared with patients with healthy livers (48 +/- 63GMU/mL vs. 10 +/- 13GMU/mL). Moreover, these IgG levels progressively increased with NASH grade (grade 1 29 +/- 37; grade 2 58 +/- 51; grade 3 84 +/- 132GMU/mL, P < 0.05). There was no relation between plasma IgG levels and NASH stage. Conclusions: Plasma IgG levels against endotoxin were found to be increased in biopsy-proven human NASH and increased with aggravated inflammation in NASH, suggesting a relationship between chronic endotoxin exposure and the severity of human NASH.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据