期刊
JOURNAL OF CLINICAL GASTROENTEROLOGY
卷 45, 期 -, 页码 S111-S114出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MCG.0b013e3182274249
关键词
epitheluim; toll-like receptors; tight junctions
资金
- Alberta Innovates
- Canadian Institutes of Health Research
- Crohns and Colitis Foundation of Canada
- Alberta IBD Consortium
Gut microbes interact with the epithelium through cell surface components, fermentation products, and extracellular secreted proteins. Host-microbial interactions primarily involve TLRs (toll-like receptors) and NLR (nucleotide-binding oligomerization domain and leucine-rich repeat containing proteins). In a strain and dose-dependent manner, several probiotic strains directly alter tight junction protein expression and/or localization in gut epithelial cells through the release of secreted compounds. Interactions between gut microbes and intestinal epithelial and immune cells are necessary for the development and maintenance of intestinal homeostasis.
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