期刊
JOURNAL OF CLINICAL GASTROENTEROLOGY
卷 42, 期 7, 页码 799-805出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MCG.0b013e318074fdfe
关键词
fecal lactoferrin; ileal pouch-anal anastomosis; cost-effectiveness; ulcerative colitis; pouchitis; inflammation; endoscopy
Background and Aims: To assess cost-effectiveness of fecal lactoferrin (FL) as the initial diagnostic approach to symptomatic patients with ilea] pouch-anal anastomosis (IPAA). Methods: Four competing strategies [empiric metronidazole therapy (txMTZ), initial pouch endoscopy with biopsy (test-Biop), initial FL assay followed by metronidazole therapy (testFL+MTZ), and initial FL assay followed by pouch endoscopy and biopsy (testFL+Biop)] were modeled in a decision tree. Results: In the base-case, the average cost per patient was $241 for testFL + MTZ, $251 for txMTZ, $405 for testFL + Biop, and $431 for testBiop. The test Biop strategy had greater effectiveness compared with txMTZ but at an incremental cost of $158 per day. The txMTZ strategy was slightly more costly and minimally more effective than testFL+MTZ with an incremental cost effectiveness of just over $12 per day. However, the testFL+MTZ strategy was associated with a 31% absolute reduction in antibiotic exposure compared with the txMTZ strategy. Conclusions: Compared with empiric metronidazole therapy, FL before treatment with metronidazole is less costly with less exposure to antibiotics and less need for endoscopy, with only marginal decrease in effectiveness.
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