期刊
JOURNAL OF CLINICAL EPIDEMIOLOGY
卷 67, 期 8, 页码 887-896出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jclinepi.2014.02.019
关键词
Inflammatory bowel disease; Crohn's; Ulcerative colitis; Epidemiology; Health administrative data; Routinely collected health data; Validation
资金
- American College of Gastroenterology
- Institute for Clinical Evaluative Sciences - Ontario Ministry of Health and Long-Term Care (MOHLTC)
- Career Development Award from the Canadian Child Health Clinician Scientist Program
- Canadian Institutes of Health Research (CIHR) strategic training program
- CIHR Chair in Reproductive and Child Health Services and Policy Research
- CIHR
- Crohn's and Colitis Foundation of Canada
Objective: Health administrative databases can be used to track disease incidence, outcomes, and care quality. Case validation is necessary to ensure accurate disease ascertainment using these databases. In this study, we aimed to validate adult-onset inflammatory bowel disease (IBD) identification algorithms. Study Design and Setting: We used two large cohorts of incident patients from Ontario, Canada to validate algorithms. We linked information extracted from charts to health administrative data and compared the accuracy of various algorithms. In addition, we validated an algorithm to distinguish patients with Crohn's from those with ulcerative colitis and assessed the adequate look-back period to distinguish incident from prevalent cases. Results: Over 5,000 algorithms were tested. The most accurate algorithm to identify patients 18 to 64 years at diagnosis was five physician contacts or hospitalizations within 4 years (sensitivity, 76.8%; specificity, 96.2%; positive predictive value (PPV), 81.4%; negative predictive value (NPV), 95.0%). In patients >= 65 years at diagnosis, adding a pharmacy claim for an IBD-related medication improved accuracy. Conclusion: Patients with adult-onset incident IBD can be accurately identified from within health administrative data. The validated algorithms will be applied to administrative data to expand the Ontario Crohn's and Colitis Cohort to all patients with IBD in the province of Ontario. (C) 2014 Elsevier Inc. All rights reserved.
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