期刊
ACTA BIOMATERIALIA
卷 17, 期 -, 页码 193-200出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2015.01.044
关键词
Block copolymer; Redox responsive; Self-assembled micelles; H-bonding associated units; Double disulfide linkage
资金
- NSFC [81071250, 91227109]
- Major Projects in National Science and Technology, Creation of Major New Drugs
- Key Projects in the National Science & Technology Pillar Program of China [2014BAI09B03]
- US NSF [CHE-1306326]
- Petroleum Research Fund [51048-ND7]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1306326] Funding Source: National Science Foundation
Redox-responsive micelles self-assembled from dynamic covalent block copolymers with double disulfide linkage in the backbone have been developed successfully. The amphiphilic block copolymers PEG PLA associated with complementary H-bonding sequences can self-assemble into spherical micelles in aqueous media with sizes from 34 nm to 107 nm with different molar mass of PEG and PLA. Moreover, in vitro drug release analyses indicate that reductive environment can result in triggered drug release profiles. The glutathione (GSH) mediated intracellular drug delivery was investigated against HeLa human cervical carcinoma cell line. Flow cytometry and fluorescence microscopy measurements demonstrated that the micelles exhibited faster drug release in glutathione monoester (GSH-OEt) pretreated HeLa cells than that in the nonpretreated cells. Cytotoxicity assay of DOX-loaded micelles indicated the higher cellular proliferation inhibition against 10 mM of GSH-OEt pretreated HeLa cells than that of the nonpretreated ones. These reduction-responsive, biodegradable and biocompatibility micelles could provide a favorable platform to construct excellent drug delivery systems for cancer therapy. (C) 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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