期刊
NEUROSCIENTIST
卷 21, 期 5, 页码 475-489出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1073858415579635
关键词
DNA methylation; memory; synaptic plasticity; DNA demethylation; epigenetics
资金
- National Institute of Mental Health [MH57014, MH091122]
- UNCF/Merck Graduate Science Research Dissertation Fellowship
- National Heart, Lung, and Blood Institute [T32HL105349]
The establishment of synaptic plasticity and long-term memory requires lasting cellular and molecular modifications that, as a whole, must endure despite the rapid turnover of their constituent parts. Such a molecular feat must be mediated by a stable, self-perpetuating, cellular information storage mechanism. DNA methylation, being the archetypal cellular information storage mechanism, has been heavily implicated as being necessary for stable activity-dependent transcriptional alterations within the CNS. This review details the foundational discoveries from both gene-targeted and whole-genome sequencing studies that have brought DNA methylation to our attention as a chief regulator of activity- and experience-dependent transcriptional alterations within the CNS. We present a hypothetical framework to resolve disparate experimental findings regarding distinct manipulations of DNA methylation and their effect on memory, taking into account the unique impact activity-dependent alterations in DNA methylation potentially have on both memory-promoting and memory-suppressing gene expression. And last, we discuss potential avenues for future inquiry into the role of DNA methylation during remote memory formation.
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