期刊
NEUROSCIENTIST
卷 22, 期 3, 页码 313-322出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1073858415581986
关键词
deep brain stimulation; stereotactic surgery; globus pallidus; subthalamic nucleus; Parkinson's disease; dystonia
资金
- CREST
- Strategic Japanese-German Cooperative Programme from Japan Science and Technology Agency
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan [26250009]
- Grants-in-Aid for Scientific Research [15H05871, 15K21731, 16K07014, 26250009, 25430021] Funding Source: KAKEN
Deep brain stimulation (DBS), applying high-frequency electrical stimulation to deep brain structures, has now provided an effective therapeutic option for treatment of various neurological and psychiatric disorders. DBS targeting the internal segment of the globus pallidus, subthalamic nucleus, and thalamus is used to treat symptoms of movement disorders, such as Parkinson's disease, dystonia, and tremor. However, the mechanism underlying the beneficial effects of DBS remains poorly understood and is still under debate: Does DBS inhibit or excite local neuronal elements? In this short review, we would like to introduce our recent work on the physiological mechanism of DBS and propose an alternative explanation: DBS dissociates input and output signals, resulting in the disruption of abnormal information flow through the stimulation site.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据