期刊
NEUROSCIENTIST
卷 21, 期 5, 页码 451-459出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1073858415579405
关键词
cocaine; addiction; silent synapse; NMDA receptor; synaptic plasticity; accumbens
资金
- National Institutes of Health [DA029565, DA035805, MH101147, DA023206, DA030379, DA034856]
- Pennsulvania Department of Health Commonwealth Universal Research Enhancement
A transient but prominent increase in the level of silent synapses-a signature of immature glutamatergic synapses that contain only NMDA receptors without stably expressed AMPA receptors-has been identified in the nucleus accumbens (NAc) following exposure to cocaine. As the NAc is a critical forebrain region implicated in forming addiction-associated behaviors, the initial discoveries have raised speculations about whether and how these drug-induced synapses mature and potentially contribute to addiction-related behaviors. Here, we summarize recent progress in recognizing the pathway-specific regulations of silent synapse maturation, and its diverse impacts on behavior. We provide an update of the guiding hypothesis-the neural rejuvenation hypothesis-with recently emerged evidence of silent synapses in cocaine craving and relapse.
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