期刊
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
卷 99, 期 12, 页码 4607-4615出版社
ENDOCRINE SOC
DOI: 10.1210/jc.2014-1851
关键词
-
资金
- Geestkracht program of The Netherlands Organisation for Health Research and Development (ZonMW) [10-000-1002]
- VU University Medical Center
- GGZ inGeest
- Arkin
- Leiden University Medical Center
- GGZ Rivierduinen
- University Medical Center Groningen
- Lentis
- GGZ Friesland
- GGZ Drenthe
- IQ Healthcare
- Netherlands Institute for Health Services Research
- Netherlands Institute of Mental Health and Addiction [Trimbos]
- NWO-VICI [91811602]
Context: Metabolic syndrome (MetS) clusters risk factors for age-related conditions including cardiovascular disease and diabetes. Shorter telomere length (TL), a cellular marker for biological age, may predict an individual's deteriorating metabolic condition. Objective: We examined whether shorter baseline TL is associated with a worse metabolic profile and with less favorable trajectories of MetS components over a 6-year follow-up. Design and Setting: Participants were part of The Netherlands Study of Depression and Anxiety, an ongoing prospective cohort study with 6-year follow-up. Participants: This study included 2848 participants age 18-65 years. Main Outcome Measures: Baseline TL from leukocytes was determined using qPCR and MetS components (waist circumference, triglycerides, high-density lipoprotein [HDL] cholesterol, systolic blood pressure, and fasting glucose) were determined at baseline, and after 2 and 6 years. Cross-sectional and longitudinal analyses were adjusted for relevant sociodemographic, lifestyle, and health factors. Results: Shorter baseline TL was cross-sectionally associated with HDL (beta = -0.016, SE = 0.008, P = .05), waist circumference (beta = 0.647, SE = 0.238, P = .007), triglycerides (beta = 0.038, SE = 0.009, P = .001), and fasting glucose (beta = 0.011, SE = 0.003, P = .001), as well as with the total number of MetS components (beta = 0.075, SE = 0.023, P = .001) and the presence of MetS (OR = 1.19; 95% CI, 1.07-1.33; P = .002). Although baseline differences progressively reduced over time, shorter baseline TL was still significantly associated with unfavorable scores of most MetS components at the 2- or 6-year follow-up. Conclusions: Cellular aging, as assessed by TL, is associated with a higher metabolic risk profile, which remains unfavorable even after a period of 6 years. These findings suggest that cellular aging might play a role in the onset of various aging-related somatic diseases via its effect on metabolic alterations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据