期刊
NEUROSCIENCE LETTERS
卷 597, 期 -, 页码 132-136出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2015.04.040
关键词
Phytic acid; Parkinson's disease; Inflammation; iNOS; NF-kappa B; ERK
资金
- Qingdao Municipal Science and Technology Commission [10-3-3-1-4-nsh]
Phytic acid (PA) is a naturally occurring constituent which exhibits protective action in Parkinson's disease (PD). Inflammation in the central nervous system (CNS) is strongly associated with neuronal death in PD. However, the molecular mechanism of the protective effect of PA in PD has not been fully elucidated. In this study, we tried to testify the protection of PA on neuron and inflammatory responses in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD model of mice and investigated the mechanism involved in them. Motor behavior test and tyrosine hydroxylase (TH) immunohistochemistry method showed PA significantly inhibited MPTP-induced dopaminergic cell loss in the substantia nigra (SN). Moreover, using immunohistochemistry method and quantitative polymerase chain reaction (qPCR), microglial activation and inducible nitric oxide synthase (iNOS) were found to be markedly repressed by PA. Via western blot assay, expressions of nuclear factor kappa B (NF-kappa B) and phosphorylated extracellular signal-regulated kinase (p-ERK) were significantly attenuated by PA. In conclusion, it is suggested that PA has a neuroprotective effect in MPTP-induced PD model and the neuroprotection is correlated with its anti-inflammatory effect which may be associated with suppression of pathways that involved in NF-kappa B and p-ERIC. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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