期刊
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
卷 97, 期 8, 页码 2670-2681出版社
ENDOCRINE SOC
DOI: 10.1210/jc.2011-3328
关键词
-
资金
- National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services [N01WH22110, 24152, 32100-2, 32105-6, 32108-9, 32111-13, 32115, 32118-32119, 32122, 42107-26, 42129-32, 44221]
- National Health and Medical Research Council, Australia
- Australian Commonwealth Department of Health and Ageing
- Danish Council for Independent Research in Medical Sciences [09-070940]
- UK Medical Research Council
- Chief Scientist Office of the Scottish Government Health Directorates
- Danish Osteoporosis Association
- Municipality of the City of Randers, Randers Central Hospital, Aarhus County, Denmark
- Pharmacy Association of 1991
- Bristol-Myers Squibb
- Eli Lilly
- Shire
- Strakan Pharmaceuticals
- Furst Medisinsk Laboratorium
- Nycomed
- National Institutes of Health
- MSD
- Roche
- Amgen
- Novartis
- Servier
- Chief Scientist Office [HSRU1] Funding Source: researchfish
- Medical Research Council [MC_UP_A620_1014, U1475000001, MC_U147585824] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0508-10082] Funding Source: researchfish
Introduction: Vitamin D may affect multiple health outcomes. If so, an effect on mortality is to be expected. Using pooled data from randomized controlled trials, we performed individual patient data (IPD) and trial level meta-analyses to assess mortality among participants randomized to either vitamin D alone or vitamin D with calcium. Subjects and Methods: Through a systematic literature search, we identified 24 randomized controlled trials reporting data on mortality in which vitamin D was given either alone or with calcium. From a total of 13 trials with more than 1000 participants each, eight trials were included in our IPD analysis. Using a stratified Cox regression model, we calculated risk of death during 3 yr of treatment in an intention-to-treat analysis. Also, we performed a trial level meta-analysis including data from all studies. Results: The IPD analysis yielded data on 70,528 randomized participants (86.8% females) with a median age of 70 (interquartile range, 62-77) yr. Vitamin D with or without calcium reduced mortality by 7% [ hazard ratio, 0.93; 95% confidence interval (CI), 0.88-0.99]. However, vitamin D alone did not affect mortality, but risk of death was reduced if vitamin D was given with calcium (hazard ratio, 0.91; 95% CI, 0.84-0.98). The number needed to treat with vitamin D plus calcium for 3 yr to prevent one death was 151. Trial level meta-analysis (24 trials with 88,097 participants) showed similar results, i.e. mortality was reduced with vitamin D plus calcium (odds ratio, 0.94; 95% CI, 0.88-0.99), but not with vitamin D alone (odds ratio, 0.98; 95% CI, 0.91-1.06). Conclusion: Vitamin D with calcium reduces mortality in the elderly, whereas available data do not support an effect of vitamin D alone. (J Clin Endocrinol Metab 97: 2670-2681, 2012)
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据