期刊
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
卷 97, 期 7, 页码 E1176-E1181出版社
ENDOCRINE SOC
DOI: 10.1210/jc.2011-2380
关键词
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资金
- Ministry of Health [IGA NS 10519-3-2009, IGA NT 11450-3-2010]
- Ministry of Education of the Czech Republic [MSM 0021620814]
- Institut National de la Sante et de la Recherche Medicale, Region Midi-Pyrenees
- Integrated Project Hepatic and Adipose Tissue and Functions in the Metabolic Syndrome (HEPADIP) [LSHM-CT-2005-018734]
- Integrated Project Molecular Phenotyping to Accelerate Genomic Epidemiology (MOLPAGE) [LSH-2003-1.1.3-1]
- Collaborative Project Adipokines as Drug Targets to Combat Adverse Effects of Excess Adipose Tissue (ADAPT) [HEALTH-F2-2008-2011 00]
Context: Obesity is associated with altered plasma levels of adipokines involved in the development of insulin resistance and obesity-related metabolic disturbances. Objective: The aim was to investigate diet-induced changes in adipokine production in sc abdominal adipose tissue (SAT) during a 6-month, multiphase, weight-reducing dietary intervention. Design, Setting, Participants, and Interventions: Forty-eight obese women followed a dietary intervention consisting of a very low-calorie diet (VLCD) (1 month), followed by a weight-stabilization (WS) period, which consisted of a low-calorie diet (2 months), and a weight-maintenance diet (3 months). Main Outcome Measures: Before and at the end of the VLCD and WS, samples of plasma and SAT were obtained. In a subgroup of 26 women, secretion of adipokines was determined in SAT explants, and in a subgroup of 22 women, SAT mRNA expression was measured. Results: Body weight decreased and insulin sensitivity increased during the intervention. Plasma levels, SAT mRNA expression, and secretion rates of adipocyte-produced adipokines (leptin, serum amyloid A, and haptoglobin) decreased during the VLCD and increased during the WS period. Adipokines produced mainly from stroma-vascular cells (IL-6, IL-8, IL-10, IL-1Ra, TNF alpha, plasminogen activator inhibitor-1, and monocyte chemoattractant protein-1) increased or remained unchanged during VLCD and decreased to levels equal to or lower than prediet levels during the WS period. The diet-induced changes in homeostasis model assessment of insulin resistance correlated with changes in leptin plasma levels during VLCD, WS, and the entire dietary intervention period. Conclusions: Diet-induced regulation of adipokine production in SAT differs according to their cellular origin (adipocytes vs. stroma-vascular cells) and diet phase (VLCD vs. WS). Insulin-sensitivity changes were associated only with those of plasma leptin. (J Clin Endocrinol Metab 97: E1176-E1181, 2012)
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