期刊
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
卷 96, 期 3, 页码 E463-E472出版社
OXFORD UNIV PRESS INC
DOI: 10.1210/jc.2010-2098
关键词
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资金
- Brigham and Women's Hospital General Clinical Research Center [M01 RR02635]
- Harvard Clinical and Translational Science Center rom the National Center for Research Resources [1 UL1 RR025758]
- NIH/NHLBI [T32-HL07901]
- NIMH [R01 MH45130]
- NCCAM [R01 AT002129]
- NINDS [R01 NS36590]
- National Space Biomedical Research Institute through NASA [NCC 9-58]
- Cephalon, Inc.
- Eli Lilly and Co.
- Johnson Johnson
- Koninklijke Philips Electronics, N.V./Philips Respironics, Inc.
- Sanofi-Aventis Groupe
- Sepracor, Inc.
- Somnus Therapeutics, Inc.
- Vanda Pharmaceuticals, Inc.
- Zeo, Inc.
- Accreditation Council of Graduate Medical Education
- American Academy of Sleep Medicine
- Duke University School of Medicine
- Harvard School of Public Health
- Mount Sinai School of Medicine
- National Academy of Sciences
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK/NIH)
- North East Sleep Society
- Office of Rare Diseases Research (NIH)
- Sanofi-Aventis, Inc.
- Society for Obstetric Anesthesia and Perinatology (SOAP)
- St. Luke's Roosevelt Hospital
- University of Virginia Medical Center
- University of Washington Medical Center
- University of Wisconsin Medical School
- American Clinical and Climatologic Association
- Koninklijke Philips Electronics, N.V.
- and ResMed
- Boehringer Ingelheim Pharmaceuticals, Inc.
- George H. Kidder, Esq.
- Gerald McGinnis
- GlaxoSmithKline
- Herbert Lee
- Hypnion
- Jazz Pharmaceuticals
- Jordan's Furniture
- Merck Co., Inc.
- Peter C. Farell, Ph.D.
- Pfizer
- ResMed
- Respironics, Inc.
- Sealy, Inc.
- Simmons
- Sleep Health Centers LLC
- Spring Aire
- Takeda Pharmaceuticals
- Tempur-Pedic
- Apollo Lighting
- Philips Lighting
- Alcon, Inc.
- Philips Respironics
- Thomas Jefferson University
- American Society for Photobiology
- Harvard University Summer School
- Illinois Coalition for Responsible Outdoor Lighting
- International Graduate School of Neuroscience
- Lightfair
- New York Academy of Science
- Utica College
- Velux
- Woolcock Institute of Medical Research
- Wyle Integrated Science and Engineering (NASA)
- Oxford University Press
Context: Millions of individuals habitually expose themselves to room light in the hours before bedtime, yet the effects of this behavior on melatonin signaling are not well recognized. Objective: Wetested the hypothesis that exposure to room light in the late evening suppresses the onset of melatonin synthesis and shortens the duration of melatonin production. Design: In a retrospective analysis, we compared daily melatonin profiles in individuals living in room light (<200 lux) vs. dim light (<3 lux). Patients: Healthy volunteers (n = 116, 18-30 yr) were recruited from the general population to participate in one of two studies. Setting: Participants lived in a General Clinical Research Center for at least five consecutive days. Intervention: Individuals were exposed to room light or dim light in the 8 h preceding bedtime. Outcome Measures: Melatonin duration, onset and offset, suppression, and phase angle of entrainment were determined. Results: Compared with dim light, exposure to room light before bedtime suppressed melatonin, resulting in a later melatonin onset in 99.0% of individuals and shortening melatonin duration by about 90 min. Also, exposure to room light during the usual hours of sleep suppressed melatonin by greater than 50% in most (85%) trials. Conclusions: These findings indicate that room light exerts a profound suppressive effect on melatonin levels and shortens the body's internal representation of night duration. Hence, chronically exposing oneself to electrical lighting in the late evening disrupts melatonin signaling and could therefore potentially impact sleep, thermoregulation, blood pressure, and glucose homeostasis. (J Clin Endocrinol Metab 96: E463-E472, 2011)
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