期刊
NEUROSCIENCE LETTERS
卷 595, 期 -, 页码 7-11出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2015.03.069
关键词
Irisin; Locomotion; Metabolism; Central nervous system
资金
- National Natural Science Foundation of China [81330010, 81390354]
- American Diabetes Association grant [1-13-BS-225]
- National Institute of Health [5R37DK043225, HL105114]
The mechanisms underlying alterations in brain functions in response to physical exercise are not fully understood. The present study examined the central effect of irisin, a 112 amino acid polypeptide hormone secreted from the skeletal muscle after exercise, on the locomotion in rats. Central administration of irisin significantly increased the locomotion. Relative to control animals treated with IgG Fc peptide, rats receiving irisin demonstrated a marked increase in total travel distance, ambulatory counts and time, and vertical counts and time. These changes were associated with a significant decrease in resting time. Central treatment of irisin also induced significant increases in oxygen consumption, carbon dioxide production and heat production, indicating an increase in metabolic activity. Our study suggests that physical activity may signal to the central nervous system to coordinate locomotion with metabolic activity via irisin. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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