期刊
NEUROSCIENCE LETTERS
卷 587, 期 -, 页码 68-71出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2014.12.027
关键词
Parkinson's disease; Single nucleotide polymorphism; GWAS; GWAS-meta-analysis; Chinese population
资金
- Major State Basic Research Development Program of China (973 Program) [2011CB510000]
- National Natural Science Foundation of China [81361120404, 81430023, 91132000, 81171198, 81371405]
Large-scale meta-analyses of genome-wide association studies in Parkinson's disease (PD) have identified a number of susceptibility loci in sporadic PD. Since the characteristics of those loci in a Han Chinese population from mainland China were unknown, we performed a case-control replication study in this population and evaluated several single nucleotide polymorphisms (SNPs) identified in a recent GWAS-meta-analysis. In total, 933 subjects comprised of 460 PD patients and 473 controls were genotyped. We found strong evidence of an association for rs708723 in RAB7L1 in the total sample (genotype p = 0.01, allelep = 0.01, OR=0.78, 95% CI = 0.65-0.94). With rs156429 in GPNMB, there was a significant difference in genotype and allele distribution between male PD patients and the control subgroup (genotype p=0.01, allele p = 0.01, OR= 0.67, 95% CI = 0.49-0.92). However, we did not observe any significant difference in genotype or allele distribution between PD and control for rs34016896 in NMD3 and rs6812193 in STBD1. (C) 2014 Published by Elsevier Ireland Ltd.
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