4.7 Article

Comparison of Simvastatin and Metformin in Treatment of Polycystic Ovary Syndrome: Prospective Randomized Trial

期刊

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
卷 94, 期 12, 页码 4938-4945

出版社

ENDOCRINE SOC
DOI: 10.1210/jc.2009-1674

关键词

-

资金

  1. Polish State Committee for Scientific Research (KBN) [2PO5E 09630]
  2. Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) [RO1 HD050656]

向作者/读者索取更多资源

Context: Polycystic ovary syndrome (PCOS) is characterized by ovarian dysfunction and hyperandrogenism; it is also associated with increased cardiovascular risks such as adverse lipid profile and endothelial dysfunction. Metformin and, more recently, statins have been shown to improve endocrine and metabolic aspects of PCOS. Objective: The aim of the study was to compare effects of simvastatin and metformin on PCOS. Design: In a prospective trial, women with PCOS (n = 136) were randomized to simvastatin (S), metformin (M), or simvastatin plus metformin (SM) groups. Evaluations were performed at baseline and after 3 months. Setting: The study was conducted at an academic medical center. Primary Outcome: The change of serum total testosterone was measured. Results: The study was completed by 113 subjects. Total testosterone decreased significantly and comparably in all groups: by 17.1, 13.6, and 15.1%, respectively, in the S, M, and SM groups. Significant decreases were also observed in all groups with respect to body mass index, C-reactive protein, and soluble vascular cell adhesion molecule-1. DHEAS declined significantly only in the S group. None of the treatments were associated with significant changes in LH or FSH. Total cholesterol and low-density lipoprotein cholesterol significantly declined only in S and SM groups. Conclusions: Simvastatin treatment was superior to metformin alone, whereas a combination of simvastatin and metformin was not significantly superior to simvastatin alone. (J Clin Endocrinol Metab 94: 4938-4945, 2009)

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据