期刊
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
卷 94, 期 10, 页码 3987-3994出版社
ENDOCRINE SOC
DOI: 10.1210/jc.2009-0292
关键词
-
资金
- Swedish Research Council [K2007-55X-11285-13-3, K2008-65x-2075301-4, 529-2002-6671]
- Swedish Foundation
- Swedish Diabetes Foundation
- Dr. P. Hakanssons Foundation
- Ake Wiberg Foundation
- Foundations of the National Board of Health and Welfare
- Jeansson Foundations
- Magn Bergvall Foundation
- Tore Nilsson Foundation for Medical Research
- Royal Physiographic Society (Nilsson-Ehle Foundation)
- VINNOVA-VINNMER
- Swedish Knowledge Foundation
- Swedish federal government
- Wellcome Trust [GR079534]
- Medical Research Council [G0600331] Funding Source: researchfish
- MRC [G0600331] Funding Source: UKRI
Context: Tenomodulin (TNMD), a putative angiogenesis inhibitor, is expressed in hypovascular connective tissues. Global gene expression scans show that the TNMD gene also is expressed in human adipose tissue and that its expression is regulated in response to weight reduction; however, more detailed information is lacking. Objective: The aim of this study was to investigate TNMD tissue distribution and TNMD gene expression in human adipose tissue in relation to obesity and metabolic disease. Design, Patients, and Interventions: TNMD gene expression, tissue distribution, and TNMD gene expression in adipose tissue from different depots, from lean and obese subjects, and during diet-induced weight reduction were analyzed by DNA microarray and real-time PCR. Main Outcome Measure: We primarily measured TNMD gene expression. Results: The TNMD gene was predominantly expressed in sc adipose tissue. TNMD gene expression was higher in sc than omental adipose tissue both in lean (P = 0.002) and obese subjects (P = 0.014). In both women and men, TNMD gene expression was significantly higher in the obese subjects compared to the lean subjects (P = 1.1 x 10(-26) and P = 0.010, respectively). In a multiple linear regression analysis, BMI was a significant independent predictor of TNMD gene expression. TNMD gene expression was down-regulated during diet-induced weight loss, with a 65% decrease after 18 wk of diet (P < 0.0001). Conclusions: We conclude that human adipose tissue TNMD gene expression is highly affected by obesity, adipose tissue location, and weight loss, indicating that TNMD may play a role in adipose tissue function. (J Clin Endocrinol Metab 94: 3987-3994, 2009)
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据