期刊
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
卷 93, 期 4, 页码 1482-1488出版社
ENDOCRINE SOC
DOI: 10.1210/jc.2007-2416
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资金
- NCRR NIH HHS [RR 024146, UL1 RR024146] Funding Source: Medline
- PHS HHS [49735, 62705] Funding Source: Medline
Background: A role of inflammation for cardiovascular disease (CVD) is established. Lipoprotein(a) [Lp(a)] is an independent CVD risk factor where plasma levels are determined by the apolipoprotein(a) [apo(a)] gene, which contains inflammatory response elements. Design: We investigated the effect of inflammation on allele-specific apo(a) levels in African-Americans and Caucasians. We determined Lp(a) levels, apo(a) sizes, allele-specific apo(a) levels, fibrinogen and C-reactive protein (CRP) levels in 167 African-Americans and 259 Caucasians. Results: Lp(a) levels were increased among African-Americans with higher vs. lower levels of CRP [< 3 vs. >= 3 mg/liter (143 vs. 108 nmol/liter), P = 0.009] or fibrinogen (< 340 vs. >= 340 mg/liter, P = 0.002). We next analyzed allele-specific apo(a) levels for different apo( a) sizes. No differences in allele-specific apo(a) levels across CRP or fibrinogen groups were seen among African-Americans or Caucasians for small apo(a) sizes (< 22 kringle 4 repeats). Allele-specific apo(a) levels for medium apo(a) sizes (22-30 kringle 4 repeats) were significantly higher among African-Americans, with high levels of CRP or fibrinogen compared with those with low levels (88 vs. 67 nmol/liter, P = 0.014, and 91 vs. 59 nmol/liter, P < 0.0001, respectively). No difference was found for Caucasians. Conclusions: Increased levels of CRP or fibrinogen are associated with higher allele-specific medium-sized apo(a) levels in African-Americans but not in Caucasians. These findings indicate that proinflammatory conditions result in a selective increase in medium-sized apo(a) levels in African-Americans and suggest that inflammation-associated events may contribute to the interethnic difference in Lp(a) levels between African-Americans and Caucasians.
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