期刊
JOURNAL OF CLINICAL DENSITOMETRY
卷 11, 期 4, 页码 503-510出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jocd.2008.03.001
关键词
Allometric scaling; bone mineral density; muscle mass; physical activity level; quadriceps strength; rehabilitation
资金
- NIA NIH HHS [1 U01 AG19069, U01 AG018832-06, U01 AG018947, U01 AG018820, U01 AG018832, 1 U01 AG18820, 1 U01 AG18832, 1 U01 AG18947, U01 AG019069] Funding Source: Medline
- NICHD NIH HHS [K12 HD001097, 5K12HD001097-08] Funding Source: Medline
This cross-sectional study examined whether reduced hip bone mineral density (BMD) is better explained by isokinetic knee extensor strength (KES), lower limb lean body mass (L-LBM). or Physical Activity Scale for the Elderly (PASE). Through population-based recruitment, 1543 adults without knee osteoarthritis were recruited. For men and women respectively, means +/- SD were age 60.8 +/- 8.0 and 61.1 +/- 7.9 yr: body mass index 29.6 +/- 4.6 and 29.1 +/- 5.4 kg/m(2): hip BMD 1.025 +/- 0.138 and 0.895 +/- 0.128 g/cm(2): KES 124.9 +/- 41 and 72.7 +/- 22.9 N . m: L-LBM 10.3 +/- 1.5 and 7.0 +/- 1.2 kg: and PASE 206.4 +/- 99.7 and 163.8 +/- 77.0. The relationship between BMD and KES in men (r(2) = 0.21, p >= 0.002) and women (r = 0.23, p < 0.001) was significant before adjustment. However, this association was no longer significant after controlling for L-LBM. Even after controlling for age, race, and sex, the association between BMD and KES was better explained by L-LBM (partial R-2 = 0.14, p < 0.001) than by PASE (partial R-2 = 0.00). Allometric scaling of KES to body size attenuated the association of BMD with KES (Std Beta = 0.03). The significant association between BMD and L-LBM (Std Beta = 0.36) remained stronger than that between BMD and weight (Std Beta = 0.21). Therefore, muscle mass accounted for a greater proportion of the variance in hip BNID than KES or activity level and explained a significant proportion of the association between weight and BMD.
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