期刊
JOURNAL OF CLINICAL ANESTHESIA
卷 24, 期 4, 页码 334-345出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jclinane.2011.07.019
关键词
Antiemetics; Postdischarge nausea and vomiting; Postoperative nausea and vomiting; Transdermal scopolamine
资金
- Abbott Laboratories
- Baxter Healthcare
- Eisai
- Merck
- Schering Plough
Transdermal scopolamine, a patch system that delivers 1.5 mg of scopolamine gradually over 72 hours following an initial bolus, was approved in the United States in 2001 for the prevention of postoperative nausea and vomiting (PONV) in adults. Scopolamine (hyoscine) is a selective competitive anatagonist of muscarinic cholinergic receptors. Low serum concentrations of scopolamine produce an antiemetic effect. Transdermal scopolamine is effective in preventing PONV versus placebo [relative risk (RR)=0.77, 95% confidence interval (CI), 0.61-0.98, P = 0.03] and a significantly reduced risk for postoperative nausea (RR=0.59, 95% CI, 0.48-0.73, P < 0.001), postoperative vomiting (RR=0.68, 95% CI, 0.61-0.76, P < 0.001), and PONV (RR 0.73, 95% CI, 0.60-0.88, P = 001) in the first 24 hours after the start of anesthesia. (C) 2012 Elsevier Inc. All rights reserved.
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