期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 56, 期 -, 页码 26-34出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2015.06.019
关键词
Vagus nerve stimulation; Major depressive disorder; The monoaminergic hypothesis of major; depressive disorder; The neural plasticity hypothesis of major; depressive disorder
资金
- Ghent Institute for Neuroscience
- Bijzonder Onderzoeksfond (BOF) from Ghent University
- Ghent University
- FWO
- BOF
- Ghent University Hospital
Vagus nerve stimulation (VNS) is a proposed neuromodulatory treatment for medically refractory major depression. Although VNS is already used in clinical practice, the underlying mechanism of action remains unknown. The present review provides an overview of the preclinical VNS studies in view of two major hypotheses in depression research: the monoaminergic and the neural plasticity hypothesis of depression. (C) 2015 Elsevier Ltd. All rights reserved.
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