期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 49, 期 -, 页码 82-89出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2014.11.020
关键词
SSRI; Serotonin reuptake inhibitor; Autism spectrum disorder; Pregnancy
资金
- Innovative Medicines Initiative (IMI) for the European Autism Interventions (EU-AIMS) project
- National Institute for Health Research Program Grant for Applied Research: Improving outcomes for people with autism spectrum disorder by reducing mental health problems
- Autism Speaks (Why do people with autism fare so differently in adult life?)
- NIHR Biomedical Research Centre for Mental Health
This study is a critical analysis of the association between selective serotonin reuptake inhibitors (SSRIs) exposure during pregnancy and autism spectrum disorder (ASD) risk in children. Electronic databases were searched for observational studies published from January 1946 to June 2014 related to the association between SSRI exposure during pregnancy and ASD in children. Studies relevant to the association between SSRI exposure during pregnancy and ASD in children were extracted and compiled for meta-analysis evaluation. Ninety-five citations were identified and seven observational studies were included. Four case-control studies were eligible for the meta-analysis and two cohort studies were narratively reviewed. The pooled crude and adjusted odds ratios of the case-control studies were 2.13 (95% Cl 1.66-2.73) and 1.81 (95% Cl 1.47-2.24) respectively. Low heterogeneity was observed between studies. The two population-based cohort studies, utilizing the same Denmark data set, have conflicting results. The findings of this meta-analysis and narrative review support an increased risk of ASD in children of mothers exposed to SSRIs during pregnancy; however, the causality remains to be confirmed. (C) 2014 Elsevier Ltd. All rights reserved.
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