期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 51, 期 -, 页码 118-125出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2015.01.009
关键词
Associative fear learning; Perceptual discrimination; Pain perception; Chronic pain
资金
- Odysseus research program Pain and Disability - Research Foundation, Flanders, Belgium (FWO Vlaanderen)
- Research Foundation, Flanders, Belgium (FWO Vlaanderen) [G.0543.09]
- KU Leuven grant [PF/10/005]
- MRC (UK) New Investigator grant
- MRC [MR/L011719/1] Funding Source: UKRI
- Medical Research Council [MR/L011719/1] Funding Source: researchfish
Recent neuropsychological theories emphasize the influence of maladaptive learning and memory processes on pain perception. However, the precise relationship between these processes as well as the underlying mechanisms remain poorly understood; especially the role of perceptual discrimination and its modulation by associative fear learning has received little attention so far. Experimental work with exteroceptive stimuli consistently points to effects of fear learning on perceptual discrimination acuity. In addition, clinical observations have revealed that in individuals with chronic pain perceptual discrimination is impaired, and that tactile discrimination training reduces pain. Based on these findings, we present a theoretical model of which the central tenet is that associative fear learning contributes to the development of chronic pain through impaired interoceptive and proprioceptive discrimination acuity. (C) 2015 Elsevier Ltd. All rights reserved.
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