期刊
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
卷 33, 期 5, 页码 580-586出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/13803395.2010.541427
关键词
Multiple sclerosis; Processing speed; Working memory; Neuropsychology; Cognitive remediation
资金
- NIH (National Institutes of Health) [HD38249]
- National Multiple Sclerosis Society [RG2596]
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [R01HD038249] Funding Source: NIH RePORTER
Cognitive symptoms of multiple sclerosis (MS) include processing-speed deficits and working memory impairment. The precise manner in which these deficits interact in individuals with MS remains to be explicated. We hypothesized that providing more time on a complex working memory task would result in performance benefits for individuals with MS relative to healthy controls. Fifty-three individuals with clinically definite MS and 36 matched healthy controls performed a computerized task that systematically manipulated cognitive load. The interval between stimuli presentations was manipulated to provide increasing processing time. The results confirmed that individuals with MS who have processing-speed deficits significantly improve in performance accuracy when given additional time to process the information in working memory. Implications of these findings for developing appropriate cognitive rehabilitation interventions are discussed.
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