期刊
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
卷 32, 期 6, 页码 645-654出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/13803390903418918
关键词
Small vessel ischemic disease; Sequential memory; Working memory; Mild cognitive impairment; Leukoaraiosis
资金
- Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development
- Rehabilitation Research and Development Service [B4602H, B6366W]
Determining the order of events is essential for accurate memory recollection: an ability previously linked to both frontal and medial temporal functioning. Frontal-subcortical and medial temporal dysfunction typify vascular dementia (VaD) and Alzheimer's disease (AD), respectively. Therefore, we assessed patients' ordering abilities using a novel sequencing task that progressively increased memory load. VaD patients made more errors and selected more previously encountered stimuli than did AD. Curve analysis revealed a general decline in ordering for VaD whereas error production in AD is more dependent on memory load. These findings generally support the role of frontal-subcortical functioning in temporal order memory.
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