期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 54, 期 -, 页码 46-56出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2014.08.014
关键词
Korsakoff; Thalamus; Amnesia; Anterograde; Retrograde; Confabulation; MRI; PET
资金
- Wellcome Trust Funding Source: Medline
In this review, the clinical, neuropsychological, and neuroimaging findings in the alcoholic Korsakoff syndrome and in thalamic amnesia, resulting from focal infarction, are compared. In both disorders, there is controversy over what is the critical site for anterograde amnesia to occur damage to the anterior thalamus/mammillo-thalamic tract has most commonly been cited, but damage to the medio-dorsal nuclei has also been advocated. Both syndromes show 'core' features of an anterograde amnesic syndrome; but retrograde amnesia is generally much more extensive (going back many years or decades) in the Korsakoff syndrome. Likewise, spontaneous confabulation occurs more commonly in the Korsakoff syndrome, although seen in only a minority of chronic cases. These differences are attributed to the greater prevalence of frontal atrophy and frontal damage in Korsakoff cases. (c) 2014 The Author. Published by Elsevier Ltd.
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