期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 52, 期 -, 页码 233-257出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2015.03.002
关键词
Obsessive-compulsive disorder; Meta-analysis; Activation-likelihood estimation (ALE); Sub-cortical; Cortical-striato-thalamo-cortical network; Executive function; Inhibition; Neuroimaging
资金
- Ministry of Education, Singapore [RGT10/13]
Obsessive-compulsive disorder (OCD) is a debilitating disorder. However, existing neuroimaging findings involving executive function and structural abnormalities in OCD have been mixed. Here we conducted meta-analyses to investigate differences in OCD samples and controls in: Study 1 - grey matter structure; Study 2 - executive function task-related activations during (i) response inhibition, (ii) interference, and (iii) switching tasks; and Study 3 - white matter diffusivity. Results showed grey matter differences in the frontal, striatal, thalamus, parietal and cerebellar regions; task domain-specific neural differences in similar regions; and abnormal diffusivity in major white matter regions in OCD samples compared to controls. Our results reported concurrence of abnormal white matter diffusivity with corresponding abnormalities in grey matter and task-related functional activations. Our findings suggested the involvement of other brain regions not included in the cortico-striato-thalamo-cortical network, such as the cerebellum and parietal cortex, and questioned the involvement of the orbitofrontal region in OCD pathophysiology. Future research is needed to clarify the roles of these brain regions in the disorder. (C) 2015 Elsevier Ltd. All rights reserved.
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