期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 55, 期 -, 页码 413-431出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2015.05.013
关键词
Hyperserotonemia; Serotonin transporters; Neuronal development; Innate immunity; Adaptive response; Neuroinflammation; Autoimmunity
资金
- Council of Scientific and Industrial Research (CSIR), Govt. of India
- Council of Scientific & Industrial Research, Govt. of India [27(0125)/03/EMR-II, miND BSC-0115]
- Department of Biotechnology, Govt. of India [BT/PR14637MED/30/561/2010]
Serotonergic system has long been implicated in the aetiology of autism spectrum disorders (ASD), since platelet hyperserotonemia is consistently observed in a subset of autistic patients, who respond well to selective serotonin reuptake inhibitors. Apart from being a neurotransmitter, serotonin functions as a neurotrophic factor directing brain development and as an immunoregulator modulating immune responses. Serotonin transporter (SERT) regulates serotonin level in lymphoid tissues to ensure its proper functioning in innate and adaptive responses. Immunological molecules such as cytokines in turn regulate the transcription and activity of SERT. Dysregulation of serotonergic system could trigger signalling cascades that affect normal neural-immune interactions culminating in neurodevelopmental and neural connectivity defects precipitating behavioural abnormalities, or the disease phenotypes. Therefore, we suggest that a better understanding of the cross talk between serotonergic genes, immune systems and serotonergic neurotransmission will open wider avenues to develop pharmacological leads for addressing the core ASD behavioural deficits. (C) 2015 Elsevier Ltd. All rights reserved.
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