期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 51, 期 -, 页码 276-295出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2015.01.007
关键词
Magnetic resonance spectroscopy; Glutamate; Glutathione; GABA; Schizophrenia
资金
- NIH [T32MH067533, R01MH094520]
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH094520, T32MH067533] Funding Source: NIH RePORTER
In vivo measurement of neurotransmitters and modulators is now feasible with advanced proton magnetic resonance spectroscopy (H-1 MRS) techniques. This review provides a basic tutorial of MRS, describes the methods available to measure brain glutamate, glutamine, gamma-aminobutyric acid, glutathione, N-acetylaspartylglutamate, glycine, and serine at magnetic field strengths of 3 T or higher, and summarizes the neurochemical findings in schizophrenia. Overall, H-1 MRS holds great promise for producing biomarkers that can serve as treatment targets, prediction of disease onset, or illness exacerbation in schizophrenia and other brain diseases. (C) 2015 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据