期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 58, 期 -, 页码 186-210出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2015.02.003
关键词
Deep brain stimulation; Striatum; Subthalamic nucleus; Globus pallidus; Substantia nigra; Electrochemistry; Voltammetry; Functional magnetic resonance imaging; Pig; Human
资金
- National Institutes of Health [R01 NS 70872]
- Grainger Foundation
- CNP
- Fundacao Araucaria
- CAPES
This review presents state-of-the-art knowledge about the roles of the basal ganglia (BG) in action-selection, cognition, and motivation, and how this knowledge has been used to improve deep brain stimulation (DBS) treatment of neurological and psychiatric disorders. Such pathological conditions include Parkinson's disease, Huntington's disease, Tourette syndrome, depression, and obsessive-compulsive disorder. The first section presents evidence supporting current hypotheses of how the cortico-BG circuitry works to select motor and emotional actions, and how defects in this circuitry can cause symptoms of the BG diseases. Emphasis is given to the role of striatal dopamine on motor performance, motivated behaviors and learning of procedural memories. Next, the use of cutting-edge electrochemical techniques in animal and human studies of BC functioning under normal and disease conditions is discussed. Finally, functional neuroimaging studies are reviewed; these works have shown the relationship between cortico-BG structures activated during DBS and improvement of disease symptoms. (C) 2015 Elsevier Ltd. All rights reserved.
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