期刊
NEUROSCIENCE
卷 309, 期 -, 页码 51-67出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2015.03.006
关键词
hippocampus; Alzheimer's disease; neurotrophins; mild cognitive impairment; plasticity degeneration
资金
- National Institute on Aging, National Institutes of Health [PO1AG014449, RO1AG043375, RO1AG042475, PO1AG025204, PO1AG107617, P30AG019610, P30AG10161]
- Alzheimer's Association
Neuroplasticity involves molecular and structural changes in central nervous system (CNS) throughout life. The concept of neural organization allows for remodeling as a compensatory mechanism to the early pathobiology of Alzheimer's disease (AD) in an attempt to maintain brain function and cognition during the onset of dementia. The hippocampus, a crucial component of the medial temporal lobe memory circuit, is affected early in AD and displays synaptic and intraneuronal molecular remodeling against a pathological background of extracellular amyloid-beta (A beta) deposition and intracellular neurofibrillary tangle (NFT) formation in the early stages of AD. Here we discuss human clinical pathological findings supporting the concept that the hippocampus is capable of neural plasticity during mild cognitive impairment (MCI), a prodromal stage of AD and early stage AD. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.
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