期刊
NEUROSCIENCE
卷 297, 期 -, 页码 211-218出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2015.03.070
关键词
cortex; arousal; atropine; c-Fos; homeostasis
资金
- National Institutes of Health [NS061841, NS062727]
- National Natural Science Foundation of China [31171049]
- Shanghai Committee of Science and Technology [11ZR1401800]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
The neural substrate of sleep homeostasis is unclear, but both cortical and subcortical structures are thought to be involved in sleep regulation. To test whether prior neuronal activity in the cortex or in subcortical regions drives sleep rebound, we systemically administered atropine (100 mg/kg) to rats, producing a dissociated state with slow-wave cortical electroencephalogram (EEG) but waking behavior (e.g. locomotion). Atropine injections during the light period produced 6 h of slow-wave cortical EEG but also subcortical arousal. Afterward, rats showed a significant increase in non-rapid eye movement (NREM) sleep, compared to the same period on a baseline day. Consistent with the behavioral and cortical EEG state produced by systemic atropine, c-Fos expression was low in the cortex but high in multiple subcortical arousal systems. These data suggest that subcortical arousal and behavior are sufficient to drive sleep homeostasis, while a sleep-like pattern of cortical activity is not sufficient to satisfy sleep homeostasis. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.
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