期刊
JOURNAL OF CIRCUITS SYSTEMS AND COMPUTERS
卷 18, 期 8, 页码 1397-1407出版社
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S0218126609005745
关键词
Neural network; classification algorithms; regulatory network; SARS
资金
- National Science Foundation of China [30700161]
- China Postdoctoral Science Foundation [20070410223]
This paper proposes to model protein regulation networks associated with severe acute respiratory syndrome (SARS) for early prediction of SARS. In the approach, specific to a patient group, a regulatory network is simulated using a fully-connected neural network and is optimized towards minimizing a novel energy function that is defined as a measure of disagreement between the input and output of the network. The nonlinear version of the network is achieved by applying a sigmoid function. Experimental results show that the proposed approaches can capture regulatory patterns associated with SARS and efficiently implement early prediction of SARS.
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