期刊
NEUROSCIENCE
卷 296, 期 -, 页码 80-91出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2014.04.048
关键词
zebrafish; monkey; neural integrator; animal models; eye movements; brainstem
资金
- Howard Hughes Medical Institute
- NIH [EY017210]
- Human Frontiers Science Program
Selection of a model organism creates tension between competing constraints. The recent explosion of modern molecular techniques has revolutionized the analysis of neural systems in organisms that are amenable to genetic techniques. Yet, the non-human primate remains the gold-standard for the analysis of the neural basis of behavior, and as a bridge to the operation of the human brain. The challenge is to generalize across species in a way that exposes the operation of circuits as well as the relationship of circuits to behavior. Eye movements provide an opportunity to cross the bridge from mechanism to behavior through research on diverse species. Here, we review experiments and computational studies on a circuit function called neural integration that occurs in the brainstems of larval zebrafish, primates, and species in between. We show that analysis of circuit structure using modern molecular and imaging approaches in zebrafish has remarkable explanatory power for details of the responses of integrator neurons in the monkey. The combination of research from the two species has led to a much stronger hypothesis for the implementation of the neural integrator than could have been achieved using either species alone. This article is part of a Special Issue entitled: Contributions From Different Model Organisms to Brain Research. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.
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