期刊
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
卷 931, 期 -, 页码 174-180出版社
ELSEVIER
DOI: 10.1016/j.jchromb.2013.05.027
关键词
Ionic liquids; Anti-hypertensives; Microextraction; Rat serum; Liquid chromatography
资金
- Department of Science and Technology (DST)
- Council of Scientific and Industrial Research (CSIR), New Delhi, India
A novel, simple and eco-friendly ionic liquid based dispersive liquid liquid microextraction followed by HPLC determination of anti-hypertensive drugs viz., eprosartan, valasartan, irbesartan, losartan and telmisartan in rat serum has been developed and validated. Experimental parameters influencing the extraction efficiency, nature and volume of the ionic liquid, dispenser solvent, extraction time and effect of salt were optimized. Under the optimum conditions, the extraction recoveries were between 92.85 and 98.50%. The relative standard deviations of intra-and inter-day accuracy varied between 1.9 and 9.1% (n=3). The linearity of the proposed method was 0.1-20 mu g/mL with coefficients of determination varying between 0.9979 and 0.9992. (C) 2013 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据