期刊
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
卷 910, 期 -, 页码 163-171出版社
ELSEVIER
DOI: 10.1016/j.jchromb.2012.09.041
关键词
Affinity chromatography; Microfluidic; mathematical modelling; separation; design strategy; beta-Amyloid binding peptides
The analytical (numerical) design of planar microfluidic affinity chromatography devices, which consist of multiple separation lanes and multiple, different surface-immobilised receptor patterns in each lane, is described. The model is based on the analytical solution of the transport-reaction equations in microfluidic systems of low Gratz number and for injection of small analyte plugs. The results reveal a simple approach for the design of microfluidic affinity chromatography devices tailored to the separation of bioanalytes, where receptors with high binding affinity are available. These devices have been designed for bioanalytical applications in mind, most notably for the proteomics field; the results are illustrated with an example using beta-Amyloid binding peptides. (C) 2012 Elsevier B.V. All rights reserved.
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