期刊
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
卷 879, 期 5-6, 页码 364-370出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jchromb.2010.12.023
关键词
Enantioseperation; Molecularly imprinted micro-solid phase extraction fiber; L- and D-tryptophan; Differential pulse anodic stripping voltammetry
资金
- Banaras Hindu University, Varanasi
- Council of Scientific and Industrial Research (CSIR), New Delhi
- CSIR [01 (2319)/09/EMR-II]
Highly efficient enantioselective separation and quantitative recoveries of D- and L-tryptophan in aqueous and real samples can be achieved, with a monolithic molecularly imprinted polymeric fiber that serves both for micro-solid phase extraction and ultratrace sensing, without any false-positive (nonspecific) contribution and cross-reactivity, in the range of 0.15-30.00 ng mL(-1) with detection limit as low as 0.0261 ng mL(-1) (relative standard deviation = 0.64%, signal/noise = 3). The proposed method combining molecularly imprinted micro-solid phase extraction fiber and a complementary molecularly imprinted polymer-carbon composite fiber sensor is proven to be useful for clinical diagnosis of stress-related diseases caused by acute tryptophan depletion. (C) 2010 Elsevier B.V. All rights reserved.
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