期刊
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
卷 878, 期 2, 页码 149-153出版社
ELSEVIER
DOI: 10.1016/j.jchromb.2009.08.040
关键词
Biacore; Binding; Biotherapeutic; Interaction; Antibody; Kinetic; Biosensor
Surface plasmon resonance (SPR) permits the quantitative analysis of therapeutic antibody concentrations anti impurities including bacteria, Protein A, Protein G and small molecule ligands leached from chromatography media The use of surface plasmon resonance has gained popularity within the biopharmaceutical industry due to the automated. label free. real time interaction that may be exploited when using this method. The application areas to assess protein interactions and develop analytical methods for biopharmaceutical downstream process development. quality control. and in-process monitoring are reviewed (C) 2009 Elsevier B.V. All rights reserved
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