期刊
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
卷 878, 期 28, 页码 2901-2904出版社
ELSEVIER
DOI: 10.1016/j.jchromb.2010.08.006
关键词
Mitoxantrone; Capillary electrophoresis; Chemiluminescence; Human urine; Human plasma
资金
- National Natural Science Foundation of China [20445002]
- Natural Science Foundation of Shanxi Province [20051022]
A novel capillary electrophoresis (CE) with chemiluminescence (CL) detection method for the determination of mitoxantrone (MTX) has been developed, which based on the CL reaction of potassium ferricyanide with luminol in sodium hydroxide medium sensitized by MTX. Under optimum analytical conditions, MTX is determined over the range of 7.0 x 10(-8)-1.0 x 10(-6) M with a detection limit of 1.0 x 10(-8) M. The relative standard deviation (RSD) was 3.7%, 2.6% and 3.0% for 7.0 x 10(-8), 5.0 x 10(-7) and 1.0 x 10(-6) M MTX (n = 11), respectively. In laboratory-built CE-CL apparatus, the proposed method has been applied to determination of MIX in commercial drug and spiked in human urine and plasma with satisfactory results. (C) 2010 Elsevier B.V. All rights reserved.
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