期刊
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
卷 874, 期 1-2, 页码 64-76出版社
ELSEVIER
DOI: 10.1016/j.jchromb.2008.09.004
关键词
Dimethyldithioarsinous acid; Dimethyldithioarsinic acid; Methylmonothioarsonous acid; Methyltrithioarsonic acid and biomolecules
资金
- JSPS, Japan
- Ministry of Education, Science, Sports and Culture [12000236, 12470509]
- Grants-in-Aid for Scientific Research [12470509] Funding Source: KAKEN
The present study describes the synthesis and characterization of thioarsenicals using electro-spray ionization-MS and time of flight-MS. Separation of thioarsenicals was found to be better by size-exclusion column compared to anion exchange column coupled with HPLC-inductively coupled argon plasma mass spectrometer (ICP MS). Although four thioarsenicals were confirmed as dimethylthioarsinous acid (m/z = 138), methylmonothioarsonous acid (m/z = 122), dimethyldithioarsinic acid (m/z = 170) and methyltrithioarsonic acid (m/z = 188), it is noted that HPLC-ICP MS alone were not sufficient for their identification. Also, none of them was stable with time. This is the first report detailing the synthesis and identification of methyltrithioarsonic acid. Both dimethyldithioarsinic acid and dimethylthioarsinous acid were detected in human nail samples while dimethyldithioarsinic acid was found in urine samples. So, the above technique could be applicable to the identification of sulfur-containing biomolecules in the biological samples. (C) 2008 Elsevier B.V. All rights reserved.
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