期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1339, 期 -, 页码 65-72出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2014.02.073
关键词
Active pharmaceutical ingredients; Aminopyridines; Genotoxic impurities; Molecularly imprinted polymers
资金
- European Commission [PITN-GA2008-214226]
This study describes the identification and evaluation of molecularly imprinted polymers (MIPs) for the selective removal of potentially genotoxic aminopyridine impurities from pharmaceuticals. Screening experiments were performed using existing MIP resin libraries to identify resins selective towards those impurities in the presence of model pharmaceutical compounds. A hit resin with a considerable imprinting effect was found in the screening and upon further investigation, the resin was found to show a broad selectivity towards five different aminopyridines in the presence of the two model active pharmaceutical ingredients (APIs) piroxicam and tenoxicam. (C) 2014 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据