期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1292, 期 -, 页码 121-131出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2012.11.051
关键词
Polygonum multiflorum; LTQ-Orbitrap; UHPLC; Anthraquinones; Stilbenes
资金
- National Natural Science Foundation of China [81073052]
- The Union CEEUSRO (Cooperation Education of Enterprise, University and Scientific Research Organization) Foundation of Guangdong Province
- Ministry of Education
- 2011A091000020 [and The Ministry of Scinece and Technology (China)]
A simple and effective method was developed for characterization of phenolic constituents in the roots of Polygonum multiflorum by combination of ultra-high-pressure liquid chromatography with linear ion trap-Orbitrap tandem mass spectrometry (UHPLC-LTQ-Orbitrap). Stilbenes, anthraquinones, tannins and naphthalenes were differentiated by diagnostic fragment ions with accurate mass measurements and characteristic fragmentation pathways. Based on the proposed strategy, fifty-nine constituents were characterized or tentatively identified, of which twenty-two constituents were the first to be reported in P. multiflorum and twelve compounds were characterized as potential new compounds. The identification and structure elucidation of these chemicals provided essential data for further phytochemical studies and quality control of P. multiflorum. The results also demonstrated that our novel method can be extended to screen and characterize other phenolic constituents and their metabolites in botanical extracts. (C) 2012 Elsevier B.V. All rights reserved.
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