期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1292, 期 -, 页码 96-103出版社
ELSEVIER
DOI: 10.1016/j.chroma.2012.09.006
关键词
Nitroimidazoles; Benzimidazoles; Chloramphenicols; Ultra-high performance liquid; chromatography; Tandem mass spectrometry
资金
- Special Fund for Agro-scientific Research in the Public Interest [201203040, 201203069]
- Chinese Universities Scientific Fund [2012QJ112]
This paper presents a sensitive and confirmatory multi-residue method for the analysis of 23 veterinary drugs and metabolites belonging to three classes (nitroimidazoles, benzimidazoles, and chloramphenicols) in porcine muscle, liver, and kidney. After extracted with ethyl acetate and basic ethyl acetate sequentially, the crude extracts were defatted with hexane and further purified using Oasis MCX solid-phase extraction cartridges. Rapid determination was carried out by ultra-high performance liquid chromatography-electrospray ionization tandem mass spectrometry. Data acquisition was performed under positive and negative mode simultaneously. Recoveries based on matrix-matched calibrations for meat, liver, and kidney ranged from 50.6 to 108.1%. The method quantification limits were in the range of 3-100 ng/kg. (c) 2012 Elsevier B.V. All rights reserved.
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