期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1310, 期 -, 页码 133-137出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2013.08.056
关键词
Ion mobility mass spectrometry; Steroids; Steroid isomers; Derivatization; Collision cross section
资金
- FinPharma Doctoral Program (FPDP)
- Magnus Ehrnrooth Foundation [ke2011n1]
- Academy of Finland [251575, 257685]
- Academy of Finland (AKA) [257685, 257685, 251575, 251575] Funding Source: Academy of Finland (AKA)
Ion mobility mass spectrometry performed in a compact traveling wave cell (TWIM-MS) is shown to provide a reliable, fast and repeatable method to separate derivatized steroid isomers. Three steroid isomer pairs were analyzed in their native form and as their p-toluenesulfonyl isocyanate derivatives. The native steroids were separated from each other, but no separation could be attained for the isomers. The derivatized steroid isomers were, however, properly separated by TWIM-MS with peak-to-peak resolutions close to or as high as baseline resolution (Rp-p = 0.77-1.08). (C) 2013 Elsevier B.V. All rights reserved.
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